HelgasonLab A leukaemia research lab

Research

Our published research:

Highlighted

Metabolism in stem cell driven leukaemia: parallels between haematopoiesis and immunity
Metabolism in stem cell driven leukaemia: parallels between haematopoiesis and immunity
Kevin M. Rattigan, Martha M. Zarou, Vignir Helgason
Blood  ·  12 Jan 2023  ·  doi:10.1182/blood.2022018258

All

2024

Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia
Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia
Ahmed Khalaf, Lucie de Beauchamp, Eric Kalkman, Kevin Rattigan, Ekaterini Himonas, …, Saverio Tardito, Mhairi Copland, David Sumpton, Emma Shanks, G. Vignir Helgason
Science Translational Medicine  ·  12 Jun 2024  ·  doi:10.1126/scitranslmed.adi5336
Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing
Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing
Martha M. Zarou, Kevin M. Rattigan, Daniele Sarnello, Engy Shokry, Amy Dawson, …, Karen Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez, G. Vignir Helgason
Nature Communications  ·  02 Mar 2024  ·  doi:10.1038/s41467-024-46114-0
Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche
Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche
Amy Dawson, Martha M. Zarou, Bodhayan Prasad, Joana Bittencourt-Silvestre, Désirée Zerbst, …, Ong Sin Tiong, Helen Wheadon, Sara Zanivan, Kristina Kirschner, G. Vignir Helgason
Nature Communications  ·  05 Feb 2024  ·  doi:10.1038/s41467-024-45471-0

2023

Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells
Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells
Kevin M. Rattigan, Zuzana Brabcova, Daniele Sarnello, Martha M. Zarou, Kiron Roy, …, Alison M. Michie, Mhairi Copland, Saverio Tardito, Eyal Gottlieb, G. Vignir Helgason
Nature Communications  ·  17 Aug 2023  ·  doi:10.1038/s41467-023-40222-z
Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells
Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells
Kevin M Rattigan, Martha M Zarou, Zuzana Brabcova, Bodhayan Prasad, Désirée Zerbst, …, Saverio Tardito, Johan Vande Voorde, Francis Mussai, Paul Cheng, G Vignir Helgason
EMBO reports  ·  25 Jul 2023  ·  doi:10.15252/embr.202256279
Unraveling Heterogeneity in the Aging Hematopoietic Stem Cell Compartment: An Insight From Single-cell Approaches
Unraveling Heterogeneity in the Aging Hematopoietic Stem Cell Compartment: An Insight From Single-cell Approaches
Fei Yang, Craig Nourse, G. Vignir Helgason, Kristina Kirschner
HemaSphere  ·  26 May 2023  ·  doi:10.1097/hs9.0000000000000895
Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death
Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death
Keith Woodley, Laura S. Dillingh, George Giotopoulos, Pedro Madrigal, Kevin M. Rattigan, …, George S. Vassiliou, Kamil R. Kranc, G. Vignir Helgason, Brian J. P. Huntly, Paolo Gallipoli
Nature Communications  ·  14 Apr 2023  ·  doi:10.1038/s41467-023-37652-0
Metabolism in stem cell driven leukaemia: parallels between haematopoiesis and immunity
Metabolism in stem cell driven leukaemia: parallels between haematopoiesis and immunity
Kevin M. Rattigan, Martha M. Zarou, Vignir Helgason
Blood  ·  12 Jan 2023  ·  doi:10.1182/blood.2022018258

2022

Mitochondrial folate metabolism inhibition drives differentiation through mTORC1 mediated purine sensing
Mitochondrial folate metabolism inhibition drives differentiation through mTORC1 mediated purine sensing
Martha M. Zarou, Kevin M. Rattigan, Daniele Sarnello, Amy Dawson, Angela Ianniciello, Karen Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez, G. Vignir Helgason
Cold Spring Harbor Laboratory  ·  21 Dec 2022  ·  doi:10.1101/2022.12.21.521404
BH3 mimetics in combination with nilotinib or ponatinib represent a promising therapeutic strategy in blast phase chronic myeloid leukemia
BH3 mimetics in combination with nilotinib or ponatinib represent a promising therapeutic strategy in blast phase chronic myeloid leukemia
Narissa Parry, Caroline Busch, Victoria Aßmann, Jennifer Cassels, Alan Hair, G. Vignir Helgason, Helen Wheadon, Mhairi Copland
Cell Death Discovery  ·  15 Nov 2022  ·  doi:10.1038/s41420-022-01211-1
E2F1 induction folowing DNA-damage and oncogene activation.
E2F1 induction folowing DNA-damage and oncogene activation.
[no publisher info]  ·  27 May 2022  ·  [no id info]
E2F1 induction following DNA damage and oncogene activation.
E2F1 induction following DNA damage and oncogene activation.
[no publisher info]  ·  27 May 2022  ·  [no id info]
Targeting ULK1 in cancer stem cells: insight from chronic myeloid leukemia
Targeting ULK1 in cancer stem cells: insight from chronic myeloid leukemia
Angela Ianniciello, G. Vignir Helgason
Autophagy  ·  01 Mar 2022  ·  doi:10.1080/15548627.2022.2041152

2021

ULK1 inhibition promotes oxidative stress induced differentiation and sensitizes leukemic stem cells to targeted therapy
ULK1 inhibition promotes oxidative stress–induced differentiation and sensitizes leukemic stem cells to targeted therapy
Angela Ianniciello, Martha M. Zarou, Kevin M. Rattigan, Mary Scott, Amy Dawson, …, Mhairi Copland, David Vetrie, Martin Ambler, Barbara Saxty, G. Vignir Helgason
Science Translational Medicine  ·  29 Sep 2021  ·  doi:10.1126/scitranslmed.abd5016
Mitochondrial metabolism as a potential therapeutic target in myeloid leukaemia
Mitochondrial metabolism as a potential therapeutic target in myeloid leukaemia
Lucie de Beauchamp, Ekaterini Himonas, G. Vignir Helgason
Leukemia  ·  24 Sep 2021  ·  doi:10.1038/s41375-021-01416-w
Folate metabolism: a re-emerging therapeutic target in haematological cancers
Folate metabolism: a re-emerging therapeutic target in haematological cancers
Martha M. Zarou, Alexei Vazquez, G. Vignir Helgason
Leukemia  ·  11 Mar 2021  ·  doi:10.1038/s41375-021-01189-2

2020

A randomised phase II trial of hydroxychloroquine and imatinib versus imatinib alone for patients with chronic myeloid leukaemia in major cytogenetic response with residual disease
A randomised phase II trial of hydroxychloroquine and imatinib versus imatinib alone for patients with chronic myeloid leukaemia in major cytogenetic response with residual disease
G. A. Horne, J. Stobo, C. Kelly, A. Mukhopadhyay, A. L. Latif, …, G. V. Helgason, L. Foroni, F. E. Nicolini, T. L. Holyoake, M. Copland
Leukemia  ·  10 Jan 2020  ·  doi:10.1038/s41375-019-0700-9
The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML
The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML
David Vetrie, G. Vignir Helgason, Mhairi Copland
Nature Reviews Cancer  ·  06 Jan 2020  ·  doi:10.1038/s41568-019-0230-9

2019

Utilizing Stimulated Raman Scattering Microscopy To Study Intracellular Distribution of Label-Free Ponatinib in Live Cells
Utilizing Stimulated Raman Scattering Microscopy To Study Intracellular Distribution of Label-Free Ponatinib in Live Cells
Kristel Sepp, Martin Lee, Marie T. J. Bluntzer, G. Vignir Helgason, Alison N. Hulme, Valerie G. Brunton
Journal of Medicinal Chemistry  ·  12 Dec 2019  ·  doi:10.1021/acs.jmedchem.9b01546
BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia
BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia
Lindsay D. Smith, Annabel R. Minton, Matthew D. Blunt, Laura I. Karydis, David A. Dutton, …, Francesco Forconi, Mark S. Cragg, David A. Tumbarello, Graham Packham, Andrew J. Steele
Leukemia  ·  28 Aug 2019  ·  doi:10.1038/s41375-019-0557-y

2018

Autophagy and mitochondrial metabolism: insights into their role and therapeutic potential in chronic myeloid leukaemia
Autophagy and mitochondrial metabolism: insights into their role and therapeutic potential in chronic myeloid leukaemia
Pablo Baquero, Amy Dawson, Gudmundur Vignir Helgason
The FEBS Journal  ·  08 Oct 2018  ·  doi:10.1111/febs.14659
The Ins and Outs of Autophagy and Metabolism in Hematopoietic and Leukemic Stem Cells: Food for Thought
The Ins and Outs of Autophagy and Metabolism in Hematopoietic and Leukemic Stem Cells: Food for Thought
Angela Ianniciello, Kevin M. Rattigan, G. Vignir Helgason
Frontiers in Cell and Developmental Biology  ·  26 Sep 2018  ·  doi:10.3389/fcell.2018.00120
Targeting quiescent leukemic stem cells using second generation autophagy inhibitors
Targeting quiescent leukemic stem cells using second generation autophagy inhibitors
Pablo Baquero, Amy Dawson, Arunima Mukhopadhyay, Elodie M. Kuntz, Rebecca Mitchell, …, Erin P. Keaney, Leon O. Murphy, Ravi K. Amaravadi, Tessa L. Holyoake, G. Vignir Helgason
Leukemia  ·  05 Sep 2018  ·  doi:10.1038/s41375-018-0252-4
hsa-mir183 EGR1 mediated regulation of E2F1 is required for CML stem progenitor cell survival
hsa-mir183/EGR1–mediated regulation of E2F1 is required for CML stem/progenitor cell survival
Francesca Pellicano, Laura Park, Lisa E. M. Hopcroft, Mansi M. Shah, Lorna Jackson, …, Ravi Bhatia, Gustavo Leone, Kamil R. Kranc, Anthony D. Whetton, Tessa L. Holyoake
Blood  ·  05 Apr 2018  ·  doi:10.1182/blood-2017-05-783845

2017

Auto-Commentary on: Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells
Auto-Commentary on: “Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells”
Lucie de Beauchamp, Pablo Baquero, Elodie M. Kuntz, Eyal Gottlieb, G. Vignir Helgason
Molecular & Cellular Oncology  ·  18 Dec 2017  ·  doi:10.1080/23723556.2017.1403532
Targeting BCR-ABL-Independent TKI Resistance in Chronic Myeloid Leukemia by mTOR and Autophagy Inhibition
Targeting BCR-ABL-Independent TKI Resistance in Chronic Myeloid Leukemia by mTOR and Autophagy Inhibition
Rebecca Mitchell, Lisa E M Hopcroft, Pablo Baquero, Elaine K Allan, Kay Hewit, …, Paolo Salomoni, Emma Shanks, Bruno Calabretta, Tessa L Holyoake, G Vignir Helgason
JNCI: Journal of the National Cancer Institute  ·  20 Nov 2017  ·  doi:10.1093/jnci/djx236
Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells
Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells
Elodie M Kuntz, Pablo Baquero, Alison M Michie, Karen Dunn, Saverio Tardito, Tessa L Holyoake, G Vignir Helgason, Eyal Gottlieb
Nature Medicine  ·  18 Sep 2017  ·  doi:10.1038/nm.4399
Axl Blockade by BGB324 Inhibits BCR-ABL Tyrosine Kinase Inhibitor Sensitive and -Resistant Chronic Myeloid Leukemia
Axl Blockade by BGB324 Inhibits BCR-ABL Tyrosine Kinase Inhibitor–Sensitive and -Resistant Chronic Myeloid Leukemia
Isabel Ben-Batalla, Robert Erdmann, Heather Jørgensen, Rebecca Mitchell, Thomas Ernst, …, Klaus Pantel, Carsten Bokemeyer, G. Vignir Helgason, Tessa L. Holyoake, Sonja Loges
Clinical Cancer Research  ·  30 Apr 2017  ·  doi:10.1158/1078-0432.ccr-16-1930

2016

ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells
ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells
Maria Karvela, Pablo Baquero, Elodie M. Kuntz, Arunima Mukhopadhyay, Rebecca Mitchell, …, Bruno Calabretta, Paolo Salomoni, Eyal Gottlieb, Tessa L. Holyoake, G. Vignir Helgason
Autophagy  ·  11 May 2016  ·  doi:10.1080/15548627.2016.1162359
Guidelines for the use and interpretation of assays for monitoring autophagy 3rd edition
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, …, Christos E Zois, Teresa Zoladek, Wei-Xing Zong, Antonio Zorzano, Susu M Zughaier
Autophagy  ·  02 Jan 2016  ·  doi:10.1080/15548627.2015.1100356

2015

Mtss1 is a critical epigenetically regulated tumor suppressor in CML
Mtss1 is a critical epigenetically regulated tumor suppressor in CML
M Schemionek, O Herrmann, M M Reher, N Chatain, C Schubert, …, C Müller-Tidow, S Li, T L Holyoake, T H Brümmendorf, S Koschmieder
Leukemia  ·  01 Dec 2015  ·  doi:10.1038/leu.2015.329

2014

Do we need more drugs for chronic myeloid leukemia
Do we need more drugs for chronic myeloid leukemia?
Tessa L. Holyoake, G. Vignir Helgason
Immunological Reviews  ·  15 Dec 2014  ·  doi:10.1111/imr.12234
The Antiproliferative Activity of Kinase Inhibitors in Chronic Myeloid Leukemia Cells Is Mediated by FOXO Transcription Factors
The Antiproliferative Activity of Kinase Inhibitors in Chronic Myeloid Leukemia Cells Is Mediated by FOXO Transcription Factors
Francesca Pellicano, Mary T. Scott, G. Vignir Helgason, Lisa E. M. Hopcroft, Elaine K. Allan, …, Mhairi Copland, Andrew Pierce, Brian J. P. Huntly, Anthony D. Whetton, Tessa L. Holyoake
Stem Cells  ·  18 Aug 2014  ·  doi:10.1002/stem.1748

2013

Role of autophagy in cancer prevention, development and therapy
Role of autophagy in cancer prevention, development and therapy
G. Vignir Helgason, Tessa L. Holyoake, Kevin M. Ryan
Essays in Biochemistry  ·  27 Sep 2013  ·  doi:10.1042/bse0550133
Autophagy in blood cancers: biological role and therapeutic implications
Autophagy in blood cancers: biological role and therapeutic implications
A. Nencioni, M. Cea, F. Montecucco, V. D. Longo, F. Patrone, A. M. Carella, T. L. Holyoake, G. V. Helgason
Haematologica  ·  01 Sep 2013  ·  doi:10.3324/haematol.2012.079061
Autophagy in Chronic Myeloid Leukaemia: Stem Cell Survival and Implication in Therapy
Autophagy in Chronic Myeloid Leukaemia: Stem Cell Survival and Implication in Therapy
Gudmundur Helgason, Arunima Mukhopadhyay, Maria Karvela, Paolo Salomoni, Bruno Calabretta, Tessa Holyoake
Current Cancer Drug Targets  ·  31 Aug 2013  ·  doi:10.2174/15680096113139990088
Targeting autophagy potentiates tyrosine kinase inhibitor induced cell death in Philadelphia chromosome positive cells, including primary CML stem cells
Targeting autophagy potentiates tyrosine kinase inhibitor–induced cell death in Philadelphia chromosome–positive cells, including primary CML stem cells
Cristian Bellodi, Maria Rosa Lidonnici, Ashley Hamilton, G. Vignir Helgason, Angela Rachele Soliera, …, Pierluigi Nicotera, Martin J. Dyer, Tessa Holyoake, Paolo Salomoni, Bruno Calabretta
Journal of Clinical Investigation  ·  01 Aug 2013  ·  doi:10.1172/JCI71197

2012

Guidelines for the use and interpretation of assays for monitoring autophagy
Guidelines for the use and interpretation of assays for monitoring autophagy
Daniel J. Klionsky, Fabio C. Abdalla, Hagai Abeliovich, Robert T. Abraham, Abraham Acevedo-Arozena, …, Teresa Zoladek, Wei-Xing Zong, Antonio Zorzano, Jürgen Zschocke, Brian Zuckerbraun
Autophagy  ·  01 Apr 2012  ·  doi:10.4161/auto.19496
Mechanisms and novel approaches in overriding tyrosine kinase inhibitor resistance in chronic myeloid leukemia
Mechanisms and novel approaches in overriding tyrosine kinase inhibitor resistance in chronic myeloid leukemia
Maria Karvela, G Vignir Helgason, Tessa L Holyoake
Expert Review of Anticancer Therapy  ·  01 Mar 2012  ·  doi:10.1586/era.12.10
Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival
Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival
Ashley Hamilton, G. Vignir Helgason, Mirle Schemionek, Bin Zhang, Svetlana Myssina, …, Carsten Müller-Tidow, Ravi Bhatia, Valerie G. Brunton, Steffen Koschmieder, Tessa L. Holyoake
Blood  ·  09 Feb 2012  ·  doi:10.1182/blood-2010-12-326843

2011

Kill one bird with two stones: potential efficacy of BCR-ABL and autophagy inhibition in CML
Kill one bird with two stones: potential efficacy of BCR-ABL and autophagy inhibition in CML
G. Vignir Helgason, Maria Karvela, Tessa L. Holyoake
Blood  ·  25 Aug 2011  ·  doi:10.1182/blood-2011-01-330621
Hydroxychloroquine for chronic myeloid leukemia: complete cure on the horizon
Hydroxychloroquine for chronic myeloid leukemia: complete cure on the horizon?
Arunima Mukhopadhyay, Gudmundur V Helgason, Maria Karvela, Tessa L Holyoake
Expert Review of Hematology  ·  01 Aug 2011  ·  doi:10.1586/ehm.11.34
The MEK inhibitor PD184352 enhances BMS-214662-induced apoptosis in CD34 CML stem progenitor cells
The MEK inhibitor PD184352 enhances BMS-214662-induced apoptosis in CD34+ CML stem/progenitor cells
F Pellicano, P Šimara, A Sinclair, G V Helgason, M Copland, S Grant, T L Holyoake
Leukemia  ·  12 Apr 2011  ·  doi:10.1038/leu.2011.67

2010

Oncogene-Induced Sensitization to Chemotherapy-Induced Death Requires Induction as well as Deregulation of E2F1
Oncogene-Induced Sensitization to Chemotherapy-Induced Death Requires Induction as well as Deregulation of E2F1
G. Vignir Helgason, Jim O’Prey, Kevin M. Ryan
Cancer Research  ·  12 May 2010  ·  doi:10.1158/0008-5472.CAN-09-2876
Targeting Chronic Myeloid Leukemia Stem Cells
Targeting Chronic Myeloid Leukemia Stem Cells
G. Vignir Helgason, Graham A. R. Young, Tessa L. Holyoake
Current Hematologic Malignancy Reports  ·  24 Feb 2010  ·  doi:10.1007/s11899-010-0043-0

2009

Targeting autophagy potentiates tyrosine kinase inhibitor induced cell death in Philadelphia chromosome positive cells, including primary CML stem cells
Targeting autophagy potentiates tyrosine kinase inhibitor–induced cell death in Philadelphia chromosome–positive cells, including primary CML stem cells
Cristian Bellodi, Maria Rosa Lidonnici, Ashley Hamilton, G. Vignir Helgason, Angela Rachele Soliera, …, Pierluigi Nicotera, Martin J. Dyer, Tessa Holyoake, Paolo Salomoni, Bruno Calabretta
Journal of Clinical Investigation  ·  01 May 2009  ·  doi:10.1172/jci35660
Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells
Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells
Svetlana Myssina, G. Vignir Helgason, Alan Serrels, Heather G. Jørgensen, Ravi Bhatia, …, Ashley Hamilton, Mirle Schemionek, Steffen Koschmieder, Valerie G. Brunton, Tessa L. Holyoake
Experimental Hematology  ·  01 Feb 2009  ·  doi:10.1016/j.exphem.2008.10.013